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Everything you need to know about IVF with PGT-A or PGD

Step 1:
Counselling session with the IVF physician in Dubai over phone call or zoom call.

Step 2:
The physician will send out the list of tests which have to be done by both the husband & wife in their city of residence in India.

Step 3:
Once the physician receives the medical reports from the couple, a treatment plan will be sent to the them. The plan will consist of a list of supplements which the couple will have to take for around 30 days. The physician will also send a diet plan that can be followed by the couple.

Step 4:
The initial part of the IVF process will be started in India itself. It will include the Ovarian stimulation from Day 2 of the periods till around Day 9. The female will have to take daily hormonal injections for the stimulation in their city itself. The patient will have to be under supervision of a gynecologist or radiologist who is well versed with trans-vaginal follicular scans for monitoring the response of the patient towards the injections used for Ovarian stimulation. (Please note, depending on the city of residence of the patient our team will try to arrange for medical assistance during the stimulation period. Our team will also arrange the medications for the patient.

Step 5:
After day 9, the couple will have to travel to Dubai & stay for a duration of around 5 days. During this visit the egg collection from the wife & semen collection from the husband will be done on day 14. After this the couple will return to India. Meanwhile, the process of fertilizing (IVF-ICSI) the eggs & sperms will be done which will result in embryos. PGT-A of all the embryos will be performed and the embryos will be kept frozen in the lab.

Step 6:
The results of the PGT-A will be sent to the couple in around 7 days. If the couple gets their desired gender embryo, then the IVF physician will prescribe a course of estrogen & progesterone tablets which will help in preparing the endometrium of the patient thus increasing the chances of the implantation of the embryo, leading to a successful pregnancy. The patient will have to come to Dubai in the subsequent month for 1 day for the embryo transfer.

Step 7:
The patient will return to India after the embryo transfer. 2 weeks after the date of transfer, the patient will have to a blood test for pregnancy (Beta HCG test) in their city. If the patient becomes pregnant then they will have a baby of their desired gender.

IVF is a fertility treatment in which a woman takes hormonal medications that cause her ovaries to produce multiple mature eggs (whereas as normally every month a woman's body produces one mature egg). The mature eggs are collected from the woman and are fertilized with the sperms outside the body in the lab which results in formations of embryos. Later the embryos are transferred back in to the uterus of the woman with the intention of establishing a successful pregnancy. The process for IVF is usually undertaken by couples who are having trouble conceiving on their own; however, for couples pursuing gender selection for family balancing, IVF is necessary even if there is no history of infertility. PGT-A (previously known as PGD, Pre-implantation genetic diagnosis) is a test done prior to the embryo implanting in the uterus; therefore, the only way to test embryos to determine their gender is through IVF with PGT-A.

PGT-A or Pre-implantation genetic testing for Aneuploidies (previously called as PGD, Pre-implantation genetic diagnosis) is a breakthrough genetic technology used for screening the embryos obtained through IVF. The test determines the genetic health of the embryos as well as the gender of the embryos. It helps to select the best embryo for transfer and improve the chance of achieving a successful pregnancy.

Over the years many couples have benefited from the use of PGT-A, Pre-implantation genetic testing for Aneuploidies (previously called as PGD, preimplantation genetic diagnosis). If you answer yes to any of the following questions then PGT-A may be helpful for you.

  • Do you want to balance your family by doing Gender selection?
  • Have you experienced several miscarriages?
  • Have you had a prior pregnancy with a chromosome abnormality?
  • Have you experienced several failed IVF cycles?
  • Has conceiving been difficult due to a low sperm count?
  • Do you or your partner carry a balanced structural chromosome rearrangement?
  • Do you or your partner have an autosomal dominant genetic disease such as Marfan syndrome?
  • Do you have a family history of Huntington disease?
  • Do you or your partner carry a recessive genetic disease such as cystic fibrosis?
  • Do you or your partner carry an X-linked genetic disease such as hemophilia or Duchenne Muscular Dystrophy?
  • Do you want to balance your family by doing Gender selection?
  • Any genetic disease or the long-term chronic ailments that could be passed on from one parent or from the both to their newborn offspring with a known mutation can be prevented using IVF and PGT-A. Some of the major genetic diseases that can be prevented using IVF and PGT-A technique include: Down Syndrome, Patau Syndrome, Edward Syndrome, Cystic Fibrosis, Tay-Sachs Disease, Sickle Cell Anemia, Spinal Muscular Atrophy, and Thalassemia.

    Yes, Gender selection is possible. PGT-A (previously known as PGD, Pre-implantation genetic diagnosis) results can describe the status of the embryo but the test does not change or alter the embryo. It will simply determine which embryos are male and which are female. As per statistical data, out of the total embryos which are formed, half of them might be male and the other half may be female. Sometimes the embryos may be chromosomally abnormal, regardless of the family history, the woman's age or previous healthy pregnancies. This means that it is possible that a family balancing patient may not find any chromosomally normal embryos of their desired gender.

    If the embryos of the desired sex are available after the testing, then 1 or 2 embryos (depends on the number of available embryos) are transferred in to the uterus of the patient. The number of embryos to transfer is a personal decision that is made together between the patient and the physician. Normally if there are more than 1 embryo of the desired sex, then we prefer transferring 1 first and keep the remaining frozen for future use. In case if pregnancy doesn’t happen in the first attempt, the patient can always come back for transfer of the frozen embryo.

    The chances of achieving a pregnancy in a particular IVF-PGT-A cycle vary widely depending on the reproductive history and age of the patient. It is important to note that even though family balancing patients often have no history of infertility, still the pregnancy cannot be guaranteed. Usually, the patients who are below the age 35 & who do not have any infertility issues, the chances of getting pregnant in the first attempt is very high almost 70-75 %.

    Before completing PGD technique, the inherited or genetic disease that one or both parents carry must be identified through genetic screening or PGD. Once the genetic abnormalities or disease has been identified, completing PGD with an IVF-ICSI cycle does not change the duration of the IVF treatment. After the egg retrieval procedure is done, the eggs are fertilized with the sperms which results in the formation of embryos. A biopsy of each embryo is taken & they are tested by using Pre-implantation Genetic (PGD) technique. After the identification of the normal looking healthy embryos, they are transferred in to the uterus. The following steps take place over 15 to 20 days.

  • Ovarian Stimulation (7 to 10 days)
  • Egg Retrieval (OPU)
  • Sperm Collection and ICSI
  • Pre-Implantation Genetic Diagnosis (PGD)
  • Embryo Transfer (ET)
  • The Pre-Implantation Genetic Diagnosis (PGD) is secured and 99% to 100% guarantee is given to the couples to select the desired sex of the embryos for pregnancy. In PGD technique the embryos are chosen and selected before pregnancy occurs, family balancing in PGD reduces the chance of termination of pregnancy, miscarriage or abortion if desired sex is not achieved in the treatment. In the IVF treatment the embryos are diagnosed using PGD technique to detect any kind of chromosomal abnormality or genetic disorder. This means that only the embryos which are healthy have the chance of being selected and transferred in to the womb. In the process of PGD, there are some left-over embryos after the IVF treatment, which can be stored in a frozen condition or embryo freezing can be done in the labortory and can be used in miscarriage case or at next pregnancy time.

    Yes, Gender selection may be completed at the same time as PGD technique and if you would like to further screen embryos for chromosomal abnormalities, Be sure and don't forget to discuss Chromosomal Screening option with your physician

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